Proprietary Science
Summary: Nature's Instincts, Dr. David Summers, FACA, has developed several all natural patent-pending, wellness and health nutraceuticals for enhanced health and fitness including aiding sleep, stamina and muscle growth. His new "Stem Cell Wellness" products accelerate muscle development, strength building, eliminates workout pain and provides restful sleep slowing the effects of aging
Stem cells are the human body's
master cells, with the ability to grow and reproduce into any one of the
body's more than 200 cell types. Recent work has demonstrated the body can
not only replace diseased, dead, or damaged existing cells with brand new
adult stem cells that carry the genetic characteristics of the replaced
cell, but with specialized exercise techniques, can slow aging and
accelerate muscle development and greatly add to the existing population
of such muscle groups.
The following information discusses the use of
natural herbal and botanical substances and their proprosed benefits on
the human body.
The life process of almost all biological species operates within a rhythmic cycle. From the highly evolved human complex to the one-celled cyanobacterium, life is lived out in a rhythm. This cycle is called the
circadian rhythm and is controlled primarily (in man) by the hypothalamous/pituitary/adrenal (HPA) glands.
The HPA complex reacts to myriad biological signals attuned to the light and dark cycles of day and night, fight or flight, hunger or satiation, heat or cold, heart rate, temperature, blood pressure and many other life or death mostly unconscious choices. Genetic signals controlling
somnolence or waking state processes working with various growth factors or modulation factors, determine whether the organism stores or dispenses energy to cells, sends the body"s stem cells and growth factors to repair damage from the awakened state and/or genetically replenishes energy stores during the sleep state.
Dysfunction of the circadian rhythm can produce disastrous results. Stem cells are the human body's master cells, with the ability to grow into any one of the body's more than 200 cell types. Directed by hormones and growth factors released in deep sleep,
stem cells can not only replace diseased, dead, or damaged cells with brand new undifferentiated stem cells caring the genetic characteristics of the replaced cell, but when this natural process is combined with specialized exercise techniques and powerful though natural
stem cell nutrients, products have been produced that can greatly add to the existing
cell population of such muscle groups accelerating muscle development,
providing increased fitness and wellness, sharper mental cognition, and more homeostasis in the body as a holistic,
ayurvedic combination of body, mind and spirit. Such a product is discussed herein.
Our products contains indium, a trace mineral proven to effect the direct uptake of essential minerals to the HPA, thereby
positively affecting the homeostasis and balance of the entire endocrine system.
Therefore, the homeostatic balance of the endocrine system is a primary
goal in any "wellness" product. These functions, aided by lipoic
acid (ALA) and acetyl L-carnitine (ACL) enhance metabolic efficiency by
increasing the efficiency of the electron transport chain. The electron
transport chain (ETC) is the intracellular process by which the
mitochondria organelles within the cell function to produce the essential
energy fuel used by the body in all living activities. This
"fuel" is adenosine triphosphate (ATP), the so-called "fuel of life".
The ECT is the back and forth shuttle of both nutrients and oxygen from
the cell membrane to the mitochondria where oxidation takes place and to
the cell nucleus for manufacture of protein.
These nutrients are catalyzed within the cell producing
an energetic gradient. The ECT also acts with anti oxidants such as
ALA and ACL as a potent scavenger of reactive oxidants, and helps drive glucose into muscle cells to
be converted to glycogen for energy and stamina. Our Product, PROstem II, combines B-vitamins with
nootrophic (enhancement of mental function) nutrient, sodium nicotinoyl-amino
butyrate, for mental acuity, memory and better mental function considered
by many once lost to youth and to be non-reversible. This produces not
only mental fitness, but a physical (mind and body) functional
enhancement.
With two potent anti inflammatories and a powerful analgesic compound making this product especially unique for the 40 to 70 age group commonly called "Baby Boomers,"
PROstem II should be considered one of the first comprehensive anti-aging products.
Stemulite II is the bimodal (morning and evening) product that provides a "circadian"
daily supplement. This product provides the enhanced daily mental energy, mental acuity, and physical stamina with an equally effective companion product for
night containing melatonin for enhancing deep relaxing sleep and REM-state dreaming for cellular repair, emotional balance and replenishment of energy stores for the next day. The following
further discusses these products and their intended effects in more detail.
What makes Natures Instincts products so unique?
Strength, stamina, accelerated muscle development (for
body-building) and maintenance of physical fitness have long been the goal of
athletes, physical trainers and trainees. Myriad training programs, diets, and combinations of regimens litter the landscape of health and fitness publications. A recent phenomenon is the recognition especially by the aging group of demographics called "baby boomers" that being fit is not just for exercise buffs, but for good health in general. However, millions of disappointed participants, millions of wasted dollars and tons of "meal replacements," huge doses of protein, creatine, amino acids, and peptide supplements have produced little or no lasting effect to the users.
Conventional wisdom shows that resistance training, such as lifting weights though requiring dedication and persistence, running, swimming, and other activities requiring repetitive total exertion, produces the greatest increase in body strength. This type of exercise causes minor injury, (micro-tears) in the muscle fibers which leads (over time) to normal muscle buildup. The older but active person wishing to maintain strength and muscle tone condemns himself to repetitive sub-clinical injury which over time manifest in multiple aches, pains, stains, stiffness and soreness. More recent research shows that strenuous exercise, taken to fatigue, produces muscle hypoxia (oxygen depletion) in the cells. Proteins released by injured muscle such as hypoxic inducible factor-1 (HIF-1), vascular endothelial growth factor (VEG-F), transforming growth factors, (TGF) and other
growth-stimulating hormones recruit bone marrow stem cells with somatic
characteristics.
De novo stem cell exposure to these factors is enough to trigger bone marrow recruitment and mobilization of somnambulant progenitor stem cells for migration to the "injured site" with "homing" and accelerated muscle buildup in humans.
Growth factor proteins act as "guides" or "chaperones" for recruiting the body's own adult stem cells.
Inevitably, as we all age, these signals diminish and cells lose their
ability to regenerate.
However, this need not be the case. We now understand
the genetic signals and the natural "effectors" that trigger muscle and tissue regeneration
leading to new strategies for strength and fitness. Certain powerful
nutrients can alter and even reverse the aging process and reestablish the
decline of aging toward optimum function. With these potent biological
modifiers, we now see regeneration of neurons and cardiomyocytes, and tissue angiogenesis for ischemic
organs. At the same time, we find that combining exercise with these
nutrients can simply provide long periods of homeostasis never possible in the past. These "wellness and anti-aging" substances long provided by nature
can slow down or even reverse the clock in both aging and regenerate diseased tissues
and is discussed below.
What is Wellness?
What is the definition of "wellness?" More than ever before, we hear this word in the news, on billboards, in conversation and even at work. Interestingly, there is no universally-accepted definition of wellness. There is, however, a set of common characteristics seen in most thoughtful attempts at a definition of wellness. We generally see a reference to a "state of well-being," which is vague, to say the least. Also frequently seen is a "state of acceptance or satisfaction with our present condition."
The truth is wellness is a tough word to define. That said, we'll leave it to
Professor Charles B. Corbin of Arizona State University who gives this definition of wellness:
"Wellness is a multidimensional state of being describing the existence of positive health in an individual as exemplified by quality of life and a sense of well-being."
Wellness is an active process of becoming aware of and making choices toward a more successful existence. Ultimately, the dimensions of wellness all fall into three broader categories, being physical, mental and metaphysical. This is critical to note, as the mental or emotional component, and most certainly the metaphysical, is often overlooked in the traditional paradigm as focus on such main staples as pain,
fatigue and chronic and acute disease factors is of overriding interest. Obviously, in order to achieve a state of wellness in our own lives or try to guide others to it, we must pay due respect to each of the dimensions. We may not all become physically fit or free from
disease to the extent we strive, but we can, however, strive for and
achieve increased wellness by working past our own self-limiting beliefs, modulating the mental angst and stress of modern day life
through use of our wonderful and uniquely human bi-cameral mind, detaching from
the emotional side of it, and finally, working with Mother Nature and her bag of wonder-nutrients that we've had the
great fortune to recently (at least in the West) to discover. These natural "super foods and nutrients" described
above may help us achieve the goals further described below.
The Adult Stem Cell - Key to Longevity and Anti Aging
With the 2002 discovery of the adult stem cell found in the bone marrow of adults by Catherine Verfaillie(1) at the University of Minnesota, it became obvious that stem cells carried an enormous potential to maintained fitness and to accelerate and enhance the building of new muscle and other tissues in the human body. John P. Cooke, et al.,(2)
of Stanford University later identified the specific
natural agonist and its' receptor for recruitment of endogenous adult stem cells for
therapeutic use in the body. His first experiments first demonstrated a mechanism of action for angiogenesis, the
de novo building of blood vessels in blood-starved limbs of animals using alkaloids is found in many different plants and botanicals. It followed that these alkaloids might not only produce new blood vessels but
by recruitment and mobilization, any tissue theoretically could be replaced, rebuilt or remolded with the body's own adult stem cells.
Which Comes First - Chicken or Egg?
Fresh, new blood is imperative to stem cell survival. Cooke showed that nicotinic alpha7-receptor on the acetylcholine receptors (nAChR) was instrumentally up-regulated during stem cell proliferation, by hypoxia in vitro, and by ischemia in vivo. Almost every cell in the body possesses this cellular receptor. The nAChR-induced network formation was partially dependent on
vascular endothelial growth factor (VEGF), and was completely dependent on the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways, which subsequently resulted in nuclear factor kappa B (NF-kappaB) activation. In vivo, pharmacological inhibition of nAChR as well as genetic disruption of
alpha7-nAChR expression significantly inhibited inflammatory angiogenesis and reduced ischemia-induced angiogenesis. Thus, for stem cell survival, the first thing on the body's agenda is immediate blood supply.
It was a "eureka moment!" when John Cooke, M.D. of Stanford
University discovered that various nicotinic receptor agonist isomers
produced this effect in mammals. This alkaloid agonist is from the solaneous nightshade family and found in eggplant extract used in
PROstem II and in Stemulite II for men and women.
Bone Marrow Stem Cell Synergistically Recruited and Mobilized
The Magical Mushroom Synergy
Cordyceps mushrooms contain polysaccharides. More recently polysaccharides, particularly the
Beta glucan 1, 3; 1, 6 (this protein molecule backbone has a multitude of sugar side-chains, each sugar energized by an oxygen molecule) found in fungal species such as
mushrooms, yeast, and barley husk. These glucans comprise long chain polysaccharide molecules, consisting of thousands to millions of glucose molecules bonded together in particular fashions.
Beta glucan has shown to function with complement (C3), a defensive protein used by the body to identify "non-self" foreign invaders.
Activation of
complement after tissue injury promotes stem cell attachment to the injury site via
complement C3 receptor (CR3) binding to incompetent C3b stem cells (iC3b) stem cells. These cells attached via CR3, provide the "second signal" that may act in concert with the
nicotinic acetylcholine receptor (nAChR) agonist (an agonist is a promoter of a biologic factor) binding
alpha 7 receptor for iC3b activation for angiogenesis required for stem cell blood supply and maturation into mature
cells. Surprisingly, the ligation (binding) of glucan to the lectin (a "sticky" protein) domain of CR3 is more efficient than the natural lectin site signal mediated by damaged tissue heparin sulphate. Cordyceps mushroom extract provides the lectin needed to bind CR3.
Proposed Mechanism of Action for Stem Cell Recruitment and
Mobilization
The synergistic action of agonistic nicotine alkoloids and beta glucan activation of
complement is the rapid recruitment and mobilization of endogenous stem cells.
When orally administered eggplant extract and mushroom
beta glucans are transported to the bone marrow and degraded oral
glucan work with acetylcholine to activate stem cells
alpha 7 receptor and via the complement system pathway binding to iC3b
receptors deposited on the stem cell. The activation of CR3 stem cells
produces the so-called "second messenger" or synergistic effect.
Therefore, it is now possible to enhance acetylcholine/glucan-mediated progenitor stem cell proliferation and expansion after an injury, such as exercise, sprain, or other damaging agents or disease event via the complement system pathway by including therapeutically affective and orally bioavailable amounts of nicotinic alkaloids
with whole glucan particles that enhance expression of acetylcholine.
This is the mechanism we use to awaken hibernating colonies of granulocytic stem cells
using them as the regeneration of hematopoietic and mesenchymal "progenitors."
The progenitor cells enter the circulation and via
chemotaxis, migrate to committed injury sites. Once there, they "home in" for later activation. After a short time, these immature cells mature and commence to differentiate and proliferate, replacing damaged or diseased cells with
brand new stem cells populations regenerating the injured or diseased tissue. This is the aim of the
stem cell recruitment products.
There are no ends to the benefits!
Additionally, fungal-derived beta (1-3, 1-6) glucans significantly enhance the
immune system, and if needed, are capable of mobilizing massive numbers of lymphocytes, and work in part by stimulating innate anti-fungal immune mechanism to fight a range of pathogenic challenges from bacteria, fungi, parasites, viruses and cancer.
Generally the glucan particles of 1.0 microns or less
(such as used in our products) are the most effective. They are taken up by both macrophages and
peyers patches in the gut where they in effect "trick" the body into assuming that it is being invaded by "non-self" pathogens. Again, biological synergy!
Brand new cells - Brand new life!
For some it is hard to imagine that the body carries such potential "immortality." Yet, case after case has demonstrated just such effects from these cells. Stem cells contribute to the body's ability to renew and repair its tissues. Unlike mature cells, which are permanently committed to their fate, stem cells can both renew themselves as well as create new cells of whatever tissue they "home" to. Mostly what we are talking about here are what scientist call stroma cells (or mesenchymal) cells from the bone marrow. They are called
pluripotent because they carry the ability to "morph" into muscle, bone, skin, cart ledge, and just about any component of the human skeleton.
Not one, but two new types of stem cells have been found that can seek out injured tissue and replace damage cells. Researchers in Italy used stem cells from blood vessels to repair muscle in mice with
muscular dystrophy. Canadian scientist found that stem cells from damaged muscle give rise to new muscle fibers.
Stem cells from bone marrow can, quite remarkably, give rise to non-marrow cells. In a 1999 report in the journal,
Nature, scientists from Boston led by Dr. Louis M. Kunkel(3) reported that they gave bone marrow transplants from normal mice to dystrophic mice. Some 12 weeks later about 10% of the muscle fibers in the diseased animals were making the correct form of
dystrophin, the protein that is defective in Duchenne Disease. For
example, bone marrow stem cells can "home in" on and repair
damaged heart, liver, pncreas, can now be found in brain tissue.
Body builders heretofore have mainly concentrated on ingesting enormous amounts of proteins and amino acids in order to replace protein stores in workout muscles. This is good to a point. The problem is that the body becomes grossly overloaded with high protein supplements that can if continued unabatedly, lead to various disease and organ dysfunction.
Until now the signals that recruit stem cells to sites of injury have been
largely unknown. Now we are beginning to understand the process.
Understanding these signals will be the key to finding new ways to replace
damaged tissues by encouraging the growth of stem cells already in the
body.
Obviously protein overload does little for the injured tissue accompanying intense
workout. The sometimes agonizing pace of muscle accumulation leads most to drop out in disappointment.
Many fitness buffs and body builders use the agonizing pace as excuse to
turn to use of illegal steroids. There is a better way! A method that does
not require or can considerably reduce such metabolic overload
without the illegal and dangerous use of anabolic steroids would be highly
desirable and would obviously find a huge market. Such a product is
discussed.
No Pain - No Gain!
Stem cell research is leading to new treatments for muscle-wasting diseases, such as muscular dystrophy, and for restoring muscle strength in elderly people. Athletes may also be interested in the new findings, which lend credence to the "no pain, no gain" approach to strength training and may lead to new strategies for bulking up. Exercise is always healthy and provides many benefits such improved circulation of blood, lymphatic, and oxygen saturation to name just a few. One may consume protein, so called growth factors, (the exception is human growth factor (hGH) which does replace fat with lean tissue) and amino acids by the ton but without exercise not much will happen.
But exercise alone does not build new muscle
unless muscles are pushed to exhaustive depletion of
oxygen. Only then are the recruitment, mobilization, homing and colonization of new muscle from stem cells decisively and effectively produce the desired results.
Athletes may also be interested in these findings, which lend credence to
the "no pain, no gain" approach to strength training and may
lead to new strategies for bulking up. Interestingly, researchers found
that stem cells from normal tissue would not multiply in culture, but
those isolated from injured (such as those micro-injured from
exercise) muscle readily proliferated and gave rise to new muscle cells.
Interestingly, human growth hormone is only released during sleep and
especially during the deep phase III and IV sleep periods. Adding small
amounts of melatonin to the evening dose of the daily/nightly dose regimen
provides this type of sleep that might otherwise be lacking in stressful
sleep.
Stem Cells Seek Out Growth Factors
Two new types of stem cells have been found that can seek out injured muscle tissue and replace the damaged cells. Researchers in Italy used stem cells from blood vessels to repair muscle in mice with muscular dystrophy. Canadian scientist found that stem cells from damaged muscle give rise to
new muscle fibers. The studies reveal how different typed stem cells repair injured muscle and point to common mechanism; damaged tissue (including exercised tissue) send out molecular signals that attract new stem cells
and needed growth factors. The denovo stem cells then multiply and form new muscle fibers, replacing and repairing injured tissue. It bears repeating that the denovo stem cells generally originate in the bone marrow - though a few are always in circulation. Following the molecular signal from the injury they "home in" to the point of injury and once there set up "colonies" of undifferentiated progenitor cells. ("Progenitor" simply means that the baby stem cells have not determined what they will be when they "grow up!") Once established in the colony, the stem cells then begin building additional micro-blood vessels, and take on the characteristics of the local cells (in this case a muscle group) multiply and form new muscle fiber. These cells replace and repair injured cells and becoming brand new cells, adding to the local population just like immigrants to new country.
The hypothesis stated above has until recently been largely unknown. Now we are able to identify and demonstrate the biological pathway of the signals (called cytokines) that recruit stem cells to sites of injury. Understanding these signals can be key to finding new ways to replace damaged tissues by encouraging the growth of stem cells already in the body. Athletes may also be interested in these findings, which lend credence to the "no pain, no gain" approach to strength training and may lead to new strategies for bulking up. Interestingly, researchers found that stem cells from
normal tissue would not multiply in culture, but those isolated from
injured muscle readily proliferated and gave rise to new muscle cells.
Great News for the Aging "Boomers"
As previously discussed, Indium helps replenish hormone levels that naturally start to fall with age. One of the theories regarding the ageing process is that it is
inevitably precipitated by the decreased production of certain hormones as we get
older, giving rise to "oh well, I'm just getting older"
acceptance of the consequence of age. It does not have to be that way! Indium appears to counteract
age-related drop-off in hormone production by stimulating hormonal
production approaching youthful levels. This includes human growth hormone (hGH), gonadotropin-releasing hormone (GnRH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). These
endrorine processes control the release of testosterone and estrogen. Indium does this by stimulating the master hormone producers - the HPA master complex system which in turn stimulates the production of over thirty hormones. These hormones then circulate throughout the body and help prevent and fight various aspects of the ageing process - for example, when supplies of growth hormone are boosted, (which also controls metabolism and affects bone density), fat is replaced with lean muscle tissue.
New research has found that indium helps improve the absorption of essential trace elements - such as copper, manganese, and chromium, copper and zinc - in the body,(4)
thereby allowing them to perform their functions more efficiently. It has also been shown to have age-related benefits, including improving memory, increasing libido,
keeping weight stable and regulating blood sugar levels.
But Wait! There are more hidden benefits!
Training causes your muscles to process natural anabolic hormones. To promote the optimum level for muscle growth, you must learn how long to train before resting and allowing your body to replace the anabolic hormones that have been used up.
Our products contain high levels of the two previously mentioned essential
nutrients, alpha lipoic acid and acetyl L-carnitine. It bears repeating
that these essential nutrients increase the supply of adenosine triphosphate (ATP) the energy required for life or as some calls it, the "currency of life."(5)
Without ATP, cells simply can not function. The combination of these two nutrients is estimated to increase energy to the nucleus of the cell by about 30%.
And here is the hidden benefit. This factor simply prevents the accumulation of
catabolic hormones that dominate when the anabolic hormones are depleted, and has enormous implications in stamina and endurance. When catabolic hormones start to dominate you will waste some of the natural anabolic (muscle building) hormone.
Mother Nature Works Her Magic
Initially researches found that heavy exercises that deplete the oxygen content of the cell caused the release of a protein called hypoxic inducible factor-1, (HIF-1). HIF tells the body that it needs oxygen. As explained above, the body immediately responds by setting out to build new blood supply in the
hypoxic zone lacking oxygen. These tiny micro vessels are primarily built by stem cells which cluster in small groups forming the new blood vessels while other stem cells begin the process of building new muscle tissue utilizing the new blood supply for nourishment. The researches found that another protein release from injured muscle, called Wnt, stimulate the stem cells to form new muscle cells of specific type. By exercising certain muscle groups to exhaustion, great numbers of stem cells can be recruited to mobilize in the muscle groups and greatly accelerate muscle development. Wnt signals the release of growth factors such
transforming growth factor (TGF), endothelial growth factor (EGF),
insulin-like growth factor (IGF), and basic fibroblast growth factor (bFGF) and other factors and hormones which supercharge the process of growth of new muscle tissue.
Wnt cooperates with HIF in directing the stem cells to adopt the characteristics of the surrounding population of cells. Interestingly, it is
Wnt that also signals new muscle tissue to form in the developing embryo.
As people age, these signals diminish and cells lose their ability to regenerate. But understanding the signals that trigger muscle regeneration could lead to new strategies for increasing muscle strength in both aging and diseased tissues. For example, Wnt has been shown recently to
stimulate the growth of autogulas adult bone marrow stem cells. Hopefully, that settled the question of whether one could "run out" of stem cells.
A Cell in Process of Dividing
Stem cells divide into one "daughter cell" which becomes differentiated into the a new phenotype with the characteristics of the surrounding cells, and one new stem cell with the same unlimited ability of de novo stem cells.
What about Super-Nutrients such as Lipoic Acid for new Cells?
Alpha lipoic acid (ALA) is a short chain fatty acid found naturally inside every cell in the
body and is considered a "super nutrient". As an essential component in the
electron transport chain (ETC), it shuttles nutrients to and from the mitochondria. It's needed by the body to produce the energy for our body's normal functions. Alpha lipoic acid converts glucose (blood sugar) into energy. Alpha lipoic acid is also an antioxidant, a substance that neutralizes potentially harmful electrons called free radicals. What makes alpha lipoic acid unique is that it
functions in water and fat, unlike the more common antioxidants vitamins C and E, and it appears to be able to recycle antioxidants such as vitamin C and glutathione after they have been used as antioxidants. Glutathione is an important antioxidant that helps the body eliminate potentially harmful substances.
Alpha lipoic acid increases the formation of glutathione. So what are the real benefits of ALA? First of all, ALA is its fantastic antioxidant effect. It's second
benefit is that it is a super anti aging supplement preventing
wrinkles, macular degeneration, liver damage from alcohol (it is called the drinking man's best friend) and for body builders, it drives more creatine into muscle cells than creatine itself. Finally, ALA has been found to prevent mitochondrial aging itself. Some scientist believes the key to very long life is in the preservation of the mitochondria.
Alpha lipoic acid is made by the body and can be found in very small amounts in foods such as spinach, broccoli, peas, Brewer's yeast, brussel sprouts, rice bran, and organ meats. But lipoic acid is greatly depleted as we age. Alpha lipoic acid supplements are available in capsule form at health food stores, some drugstores, and online. For maximum absorption, the supplements should be taken on an empty stomach. However, very high amounts taken on an empty stomach may cause indigestion. I prefer to take ALA with some food.
PROstem II contains 200 mg of
racemic ALA providing the maximum amount usable for the body.
Diabetes and Peripheral Neuropathy - Medical Effects Worth
Mentioning
Peripheral neuropath can be caused by injury, nutritional deficiencies,
and chemotherapy or by conditions such as diabetes, Lyme disease, alcoholism, shingles, thyroid disease, and kidney failure. Symptoms can include pain, burning, numbness, tingling, weakness, and itching. Alpha lipoic acid works as an antioxidant in both water and fatty tissue, enabling it to enter all parts of the nerve cell and protect it from damage.
ALA is one of Mother Nature's best managers of excess glucose in diabetes as it takes excess sugar from the blood and shuttles it into muscle where it is converted to glycogen for energy. More importantly, lipoic acid is essential in transporting nutrients to and from the mitochondria of every cell in the body. It is part of the electron transport chain in and out to the mitochondria carrying vital energy producing nutrients and vitamins to the mechanism of the Krebs cycle which produces adenosine triphosphate (ATP), essential for every function of the body. Maximum intake of lipoic acid can add as much as 30%
increase in ATP production with concurrent increases in whole body energy, strength, and stamina.
In one of the largest studies on the use of alpha lipoic acid in chronic
fatigue syndrome, 181 people took 600 mg, 1200 mg or 1800 mg of alpha lipoic acid a day or a placebo. After 5 weeks, alpha lipoic acid improved chronic fatigue
symptoms in 90%. The dose that was best tolerated while still providing benefit was 600 mg once daily.
Brain Function
Alpha lipoic acid can cross the blood-brain barrier, (BBB) a wall of tiny vessels and structural cells, and pass easily into the brain. Once inside the BBB, it may be able to help protect brain and nerve tissue
from build up beta amyloidal plaques.
Age-Related Conditions
As an antioxidant, alpha lipoic acid is extremely efficient in neutralizing free radicals which can damage cells. Free radical damage is known to contribute to aging and chronic illness.
Other Conditions
Alpha lipoic acid has also been suggested for cataracts, glaucoma, multiple sclerosis, burning mouth syndrome, Alzheimer's disease and stroke, but large, well-designed studies are needed to see if it's effective for these conditions.
The L-Carnitine "Connection" - The Sum of the Parts is Greater Than the Whole!
According to Dr. Ray Sahelian, M.D. a prominent nutritional expert, Acetyl L-Carnitine supplement treatment provides important health benefits for mental functional enhancement as well as for muscle and skeletal benefits. L-Carnitine and Alpha lipoic Acid in research studies are reported
to combine, creating one of the most powerful mental energizers one can
take.
Acetyl L-carnitine (also spelled as acetyl l- carnitine, or l-acetylcarnitine) and simply carnitine (let's just call it ALC) play several important roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group of acetyl l carnitine is used to form acetyl-Co-Al, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, ALC serves as an energy reservoir of acetyl groups and both acetylcarnitine and carnitine help improve energy production. The acetyl group of ALC is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps ALC can even act as a neurotransmitter itself. What you may notice by taking an acetylcarnitine supplement is an increase in physical, but not as much as an increase in mental energy, focus, acuity, memory and sharper ideation. The mind boosting effect of ALC is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement.
Acetyl carnitine has a significantly more immediate and noticeable mental effect than carnitine because it crosses into the brain much better. The mind boosting effect of ALC is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement. Carnitine is produced in the kidneys and liver, and its main job is to carry fatty acids into the mitochondria. In addition, carnitine protects cells in the heart muscle from damage when a heart attack or spasm cuts off the oxygen supply. One study shows that patients who took 2 grams of L-carnitine a day for four weeks cut the number of complications from a heart attack (angina, heart rhythm disturbances and heart failure) in half.
PROstem II contains 250 mg. per tablet.
L-carnitine also gives the body a boost in energy levels. The release of fat makes LC important in weight loss or exercise regimens because it helps convert body fat into fuel. It also raises levels of certain enzymes needed to metabolize sugars, starches and other
carbohysdrates. A supplement of L-carnitine promotes stamina when used with an exercise program, while also reducing production of lactic acid, which causes that burning feeling in the muscles.
A few more words about Indium Sulfate
The endocrine system is controlled by the hypothalamus/pituitary/adrenal (HPA) complex in the brain. Growth factors such as bFGF, TGF, IGF-1, IGF-2, EGF, VEGF, human
gonadotropin hormone (hGRH) follicle simulating hormone (FSH), HIF, and Wnt and many others are all involved in tissue repair and growth. Many researchers have concluded that
indium is instrumental in modulating the release of these hormones by mediating the uptake of essential minerals and mineralocorticoids which in turn produce a balancing effect of the entire 30-plus hormones of the human endocrine system
but also regulate salt and potassium in the extra cellular fluids of the tissue. Anyone who has ever suffered painful cramps from strenuous exercise knows the importance of the depleted aldosterone of which 90% is mineralocorticoids. When exercise is intense and carried out to fatigue, oxygen is depleted from the muscle and HIF and Wnt are released. However, dependant on the HPA is the release growth factors such as testosterone, insulin-like growth hormone (IGF-1), from the
pituitary, HGH from the hypothalamus, and the adrenals that signal the nervous system to prepare to call on unbelievable strength when challenged. This signal mobilizes the respiratory and circulatory systems of the body for intense action. Reserve energy in the body is called upon, and functions are diverted away, and other natural anabolics are facilitated by the healthy and balanced
HPA. Acetylcholine and glutamine are co-regulated by the hypothalamus. This neurotransmitter agonist must be activated to stimulate and awaken somnambulant bone marrow stem cells that mobilize with HIF and Wnt directing the migration and homing in to the hypoxic zone. Cooke demonstrated that progenitor stem cells are attracted to the release of acetylcholine binding to the acetylcholine receptor agonist (AChR-A), especially the nicotinic receptor, alpha 7.
While Indium has been safely used for decades in medicine (it is used in diagnostic imaging) and has FDA approval for this use, and it would take 20,000 time more than used in dietary supplements for become toxic, its use in nutritional supplements is new. Some reports say that within 5-10 days Indium begins producing lower body weight, in fact it is thought to this via stimulation of human growth hormone (HGH) with is know to replace body fact with muscle. Other reports from athletes say within 5-10 days, the strenuous exerciser, who normally stops exercising due to muscular pain, should be able to increase repetition by 10%-20%. In one sturdy of 15 male Kung Fu practitioners taking 5 mg of Indium per day demonstrated a 20% increase in stamina and endurance at two months. In another study of distance runners, after two weeks of Indium supplement at the same (5mg) dose, demonstrated a 30% increase in stamina and endurance.
A Most Astonishing Enzyme - Serratiopeptidase
Serratiopeptidase (also called serrapeptase) used in
all our fitness products is a super protein digesting enzyme which breaks down 'non living' matter in the human body. This action may promote a reduction in levels of dead tissue in the circulatory system, promoting smoother healthier flowing blood. Fibrin may build up throughout the body and manifest in many undesirable and unhealthy ailments. Serrapeptase fights fibrin build up in the cardiovascular system, organs and muscle tissue.
One of its primary actions in relieving osteoarthritis pain is its ability
to break down and remove fibrin commonly found arthritic knees. This is
extremely important since inflammatory neutrophils (white cells) are
highly attracted to these sites. When the fibrin is broken down and
removed, the inflammation is resolved and pain is abolished!
Originally serrapeptase, a proteolytic enzyme isolated from the non-pathogenic bacteria
Serratia species found in the digestive tract of the Japanese silkworm had astounding health benefits. The silk worm uses this power enzyme to dissolve and extract himself from its cocoon as it matures into a moth or butterfly. Although non-pathogenic, the
Serratia bacteria occasionally produced a pneumonia-like disease in some severely immunocompromised patients.
Now this enzyme that was originally noticed over 30 years ago is being used
made through recombinant DNA instead of the bacterial production.
Natures Instincts' scientist have taken the process one step further and use a genetically modified yeast that produces the purest form of the enzyme for specifically cleaving the
leucine amino acid bond to other peptides. Once this amino acid protein binding site is broken, the dead, diseased, or inflamed proteins are safely and effectively broken away from healthy tissue and removed along with accumulated static fluids from the
body.
Hans Nieper, M.D., a German doctor and scientist, discovered the natural enzyme over 20 years ago. It has been used in both Japan and Europe for several years as a natural alternative for pain relief but was not introduced into the U.S. until 2002. Much of Nieper's research with serrapeptase was with clogged arteries. He discovered that only a small amount, if taken every day for 18 months, would complete the healing of clogged arteries and they would be almost entirely clear.
Further research has been done, primarily in Japan, and they have discovered that serrapeptase
safely dissolves away any dead tissue anywhere in the body and this naturally causes less pain and in many cases NO MORE PAIN. (In fact it is rumored that this is what the doctors take when they have pain). Once the tissue is dissolved it is disposed of through the body's normal channels. One
our users, Dan Clevenger of Columbus Ohio, wrote: "I have never taken anything like this for such relief for chronic back pain. I simply could not live without it."
It is now set to become the most revolutionary and widely used natural alternative to anti-inflammatory drugs without the side effects. The use of leucine amino acid peptidase (LAD) as an anti-inflammatory has become widespread throughout Europe and America during the last few years without any known side effects.
Summary
This supplement contains a rare trace mineral called Indium. The FDA has approved Indium for intravenous use in medicine as a contrast media enhancer for radiology studies. This product contains leucine amino acid peptidase (LAD) a natural anti-inflammatory and dead tissue remover.
Two extremely powerful and effective anti oxidant/anti inflammatories, ALA
and ALC are used in their highest effective doses. Additionally, B-complex
and D vitamins are used in their highest doses. A caffeine/guarana
combination providing a 5-hour energy plateau of increased mental function
with noticeable memory and concentration improvement from sodium
nicotinoyl-amino butyrate for level II function produces the unrivaled
mind/body synergy and coordination reported by so many users.
Three ingredients; the trace mineral
indium and an eggplant alkaloid from the solanaceae family (the nightshade genus; tomatoes, eggplant, tobacco, etc.)
and mushroom extract containing beta glucan comprise the basic ingredients for exogenous stem cell recruitment for accelerated muscle development and greatly increased strength and energy.
Just as importantly, these same stem cells repair and replace damaged cells from skin, bone, organs and tissue such as the fascia around exposed bone producing
osteoarthritis. PROstem II added additional proteins, amino acids, fatty acids, immune enhancing polysaccharides (protein/sugars) and
serratiopeptidase, a powerful protolytic enzyme and analgesic for pain relief into the supplement. It is nutritionally equal or superior of any of the current high-protein strength and energy products providing natural analgesic relief from chronic and acute pain.
No other product is capable of producing the
multifaceted non-steroidal effects that are proven to use the body's own stem cell population to enhance immunity, reduce or eliminate both chronic and acute pain while accelerating muscle development, and increasing strength, energy, and long-term endurance. None of
our competition has the capability of reducing body fat, eliminating post-workout muscle soreness and pain,
while providing rapid strength recover after workout. This combination of all-natural products can produce the feeling of "wellness" and vitality with a zest for life like no other product!
All dietary supplements used conform to the FDA
"generally regarded as safe" or GRAS categories.
Dr. David Summers, FACA
October 21, 2011 - All rights reserved
1. Catherine Verfaillie: Pluripotency of mesenchymal stem cells derived from adult marrow Nature 418, 41-49 (4 July 2002).
2. John P. Cooke: Stem Cell Therapy for Vascular Regeneration. Circulation, 2010; August 3; 122(5): 517-526.
3. Louis M. Kunkel, et. al: Somitic origen of limb muscle satellite and side population cells, Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 945-950.
4. Dr. Robert Lyons, ND: Indium - The Missing Trace Mineral, New Health Press, Henderson NV, 2001
5. Jiangang Long, et al: Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-L-carnitine, Neurochem Res. 2009, April; 34(4): 755-763.
The Statements on this document are partially based
on these scientific studies:
1.
Aging of tissue-resident adult stem/progenitor cells and their
pathological consequences. Panminerva Med. 2009 Jun;51 (2):57-79
2.
Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. Free Radic Biol Med. 2010 Nov 30;49(10):1494-504. Epub 2010 Aug 12.
3.
Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol int. 2010 Jul;10 Suppi 1:S99-106. 16
4.
Treatment of alcohol-related liver disease with thioctic acid: a six month randomised double-blind trial. Gut. 1982 Dec; 23(12):1088-93.
5.
L-camitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptom: Cardiology. 2010;116(3):178-82. Epub 2010 Jul
6.
Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest. 2010 Feb;40(2):148-54. Epub 2009 Dec 27.
7.
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci. 2009 Aug 15;283(1-2):199-206. Epub 2009 Apr 1.
8.
Activation of innate immunity to reduce lung metastases in breast cancer. Cancer Immunol Immunother. 2010 May; 59(5):789-97. Epub 2009 Dec 3.
9.
Protective Effects on Mitochondria and Anti-Aging Activity of Polysaccharides from Cultivated Fruiting Bodies of Cordyceps militaris. Am J Chin Med. 2010;38(6):1093-106.
10.
Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci. 2010; 113(4):395-403
11.
The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic. J Int Soc Sports Nutr. 2010 Feb 15;7:10
12.
The effects of caffeine ingestion on time trial cycling performance. J Sports Med Phys Fitness. 2008 Sep;48(3):320-5.
13.
Guarana's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink. Evid Based Complement Altemat Med. 2007 Dec 5.
14.
Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome - Eksp Klin Farmakol. 2009 Jul-Aug;72(4):15-9.
15.
Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation. Indian J Pharm Sci. 2010 Jan;72(1):65-71.
16.
Effects of folic acid supplementation on serum folate and plasma homocysteine concentrations in older adults: a dose-response trial. . Am J Epidemiol. 2010 Oct 15;172(8):932-41. Epub 2010 Sep 16.
17.
Indium - New Mineral Discovery of the 21st. Century, 2003, J.B. Marion, Publisher: Information Pioneers, South Woodstock, Conn
Diclaimer The information in this document has not been approved by the U.S. Food and Drug Administration. These products are not intended to treat, prevent or cure any disease. Do not take any nutritional products before consulting with your physician first Please also note that this letter is from Dr. Summers and information and opinions are his own, not , Nature's Instincts, Inc.
